Featured publications

Gao X*, Zhang J*, and Tamplin O*.

The aging hematopoietic stem cell niche.

Frontiers in Hematology, 2025 (*co-corresponding authors)

Gao X*, Carpenter R, Boulais PE, Zhang D, Marlein CR, Li H, Smith M, Chung D, Maryanovich M, Will B*, Steidl U*and Frenette PS.

Regulation of the hematopoietic stem cell pool by c-Kit-associated trogocytosis.

Science, 2024 (*co-corresponding author)

Rajagopalan A, Feng Y, Gayatri MB, Ranheim EA, Klungness T, Matson DR, Lee MH, Jung MM, Zhou Y, Gao X, Nadiminti KV, Yang DT, Tran VL, Padron E, Miyamoto S, Bresnick EH, Zhang J.

A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.

J Clin Invest. 2023

Gao X, You X, Droin N, Banaszak L, Churpek J, Padron E, Geissler K, Solary E, Patnaik MM and Zhang J.

Role of ASXL1 in hematopoiesis and myeloid diseases.

Exp. Hematol., 2022

Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J.

Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras Q61R/+ mice. Leukemia, 2022

Ma L*, Tang Q*, Gao X, Lee J, Lei R, Suzuki M, Zheng D., Ito K, Frenette PS, and Dawlaty MM., Tetmediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis,

Science Advances. 2022

You X*, Liu F*, Binder M*, Vedder A*, Lasho T*, Wen Z, Gao X, Flietner E, Rajagopalan A, Zhou Y, Finke C, Mangaonkar A, Liao R, Kong G, Ranheim EA, Droin N, Hunter A, Nikolaev S, Balasis M, Abdel-Wahab O, Levine R, Will B, Nadiminti K, Yang D, Geissler K, Solary E, Xu W, Padron E, Patnaik MM, Zhang J.

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation.

Blood, 2022

Zhang D, Gao X, Li H, Wei Q, Pinho S, Yang E, & Frenette PS.

The microbiota regulates haematopoietic stem cell function through local iron availability in bone marrow.

Cell Stem Cell. 2022

Tchernychev B, Li H, Lee SK, Gao X, Ramanarasimhaiah R, Liu G, Hall KC, Bernier SG, Jones JE, Feil S, Feil R, Buys ES, Graul RM, Frenette PS, Masferrer JL.

The sGC stimulator olinciguat attenuates inflammation, vaso-occlusion and nephropathy in mouse models of Sickle cell disease.

Br J Pharmacol., 2021

Gao X, Zhang D, Xu C, Li H, Caron KM, and Frenette PS.

Nociceptive nerves regulate haematopoietic stem cell mobilization.

Nature. 2021

Wei Q, Nakahara F, Asada N, Zhang D, Gao X, Xu C, Alfieri A, Brodin NP, Zimmerman SE, Mar JP, Guha C, Guo W and Frenette PS.

Snai2 maintains bone marrow niche cells by repressing osteopontin expression.

Dev Cell. 2020

Xu C, Gao X, Wei Q, Nakahara F, Zimmerman SE, Mar J, Frenette PS.

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.

Nature Communications. 2018

Gao X, Xu C, Asada N, Frenette PS.

The hematopoietic stem cell niche: from embryo to adult.

Development. 2018

Mclver SC, Hewitt KJ, Gao X, Mehta C, Zhang J, Bresnick EH.

Dissecting Regulatory Mechanisms Using Mouse Fetal liver-derived erythroid Cells.

Methods Mol Biol. 2018

Mehta C, Johnson KD, Gao X, Ong IM, Katsumura KR, Mclver SC, Ranheim EA, and Bresnick EH. Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.

Cell Rep. 2017

Katsumura KR, Bresnick EH, and the GATA Factor Mechanisms Group (Gao X, Hewitt KJ, Matson DR, Mclver KC, Mehta C, Soukup AA, Tanimura N, Shi L, Johnson KD).

The GATA factor revolution in hematology.

Blood. 2017

Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E and Zhang J.

p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.

Blood. 2017

Gao X, Wu T, Johnson KD, Lahvic JL, Ranheim EA, Zon LI, Bresnick EH.

GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis.

Stem Cell Reports. 2016

Hewitt KJ, Johnson KD, Gao X, Keles S, and Bresnick EH. The Hematopoietic Stem and Progenitor Cell Cistrome:

GATA Factor-Dependent cis-Regulatory Mechanisms.

Curr. Top. Dev. Biol. 2016

Johnson KD*, Kong G*, Gao X, Chang YI, Hewitt KJ, Sanalkumar R, Prathibha R, Ranheim EA, Dewey CN, Zhang J and Bresnick EH.

Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Science Advances. 2015

Sanalkumar R, Johnson KD, Gao X, Boyer ME, Chang YI, Hewitt KJ, Zhang J and Bresnick EH. Mechanism governing a stem cell-generating cis-regulatory element.