The overarching goal of the Gao lab's research is to understand the functional roles of bone marrow microenvironment in regulating hematopoietic stem cells (HSCs) during normal, pre-malignant and malignant hematopoiesis.
Current projects focus on three general areas:
1) Understand the functions of nociceptive nerves in regulating HSC behavior and blood diseases; 2) Explore the contributions of aged bone marrow microenvironment to age-related blood diseases; 3) Investigate the roles of macrophages in the HSC niche.
My laboratory combines in vivo and in vitro approaches, including molecular and cellular techniques, mouse models as well as patients-derived xenotransplantation models. Ultimately, we hope that our research will help inform the development of novel strategies to advance the diagnosis, prevention and treatment of blood disorders.
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